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Hypervitaminosis D C1442839

Published: July 22, 2026Updated: August 20, 2026

Excess vitamin D buildup in the body, usually from over-supplementation. It can cause weakness, kidney problems, and high calcium levels. Treatment involves stopping vitamin D and fluids.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E67.3
ICD-11
5A00.0
Body system
toxicologic
Severity
moderate
Chronic
false

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(toxicologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Varies

Weakness

(general)

Polyuria

(renal)

Constipation

(gastrointestinal)

Kidney stones

(renal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Discontinue vitamin D supplements

Immediate discontinuation of all vitamin D supplements and any vitamin D-containing medications. Assessment of other medications that may contribute to hypercalcemia is essential.

medication
2

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Dietary calcium restriction

Temporary reduction of calcium-rich foods including dairy products, fortified foods, and certain fish. Maintain adequate but not excessive calcium intake during recovery period.

dietary

Additional treatment options

Bisphosphonate therapy

For significant hypervitaminosis D with hypercalcemia, bisphosphonates may be prescribed to reduce calcium release from bones and lower serum calcium levels.

medication

Serum calcium and vitamin D monitoring

Frequent laboratory monitoring of serum calcium, vitamin D (25-OH), and parathyroid hormone levels until normalization. Critical for guiding treatment duration and intensity.

monitoring

Increased hydration

Enhanced fluid intake to promote urinary calcium excretion and prevent kidney complications. Sodium and potassium intake may also be adjusted to support calcium homeostasis.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Hypervitaminosis D C1442839?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. J Clin Endocrinol Metab. 2020.

guideline2020
2

Marzolla V, Feraco A, Limana F, et al. Hypervitaminosis D: Pathophysiology and Clinical Management. Endocr Rev. 2022.

review2022
3

Chen S, Patel KP, Wang Z, Robinson TW. Vitamin D Toxicity in Adults: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2021.

meta_analysis2021
4

Kumar R, Sternberg M, Singh R. Vitamin D Intoxication and Hypercalcemia. In: Williams Textbook of Endocrinology. 14th ed. Elsevier; 2023.

other2023

Medication Comparisons

Compare medications used to treat Hypervitaminosis D C1442839. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy