Hypoalphalipoproteinemia Primary 1 C5231558
Low HDL cholesterol due to genetic causes. HDL is the good cholesterol that helps remove other fats from blood. This raises heart disease risk and is managed with medications and lifestyle changes.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Premature coronary artery disease
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Low HDL cholesterol
(metabolic)Xanthomas
(integumentary)Peripheral neuropathy
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aerobic Exercise Program
Regular moderate-intensity aerobic exercise such as walking, swimming, or cycling for at least 150 minutes per week has been shown to increase HDL cholesterol levels and improve overall cardiovascular health outcomes in patients with lipid disorders.
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
HDL-Boosting Nutritional Plan
A heart-healthy dietary pattern emphasizing monounsaturated fats from olive oil and nuts, omega-3 fatty acids from fatty fish, and soluble fiber while reducing refined carbohydrates and saturated fats to support lipid profile improvement.
Additional treatment options
Lipid Panel Monitoring
Serial lipid profile testing every 3-6 months to track HDL trends and assess cardiovascular risk progression or improvement with lifestyle interventions.
monitoringHDL-Targeting Pharmacotherapy
Pharmacologic agents that may be considered when lifestyle modifications are insufficient, targeting pathways to modestly raise HDL levels and reduce overall cardiovascular risk in consultation with a lipid specialist.
medicationNiacin Supplementation
Niacin (vitamin B3) supplementation may be considered as adjunctive therapy to raise HDL levels, though clinical benefits in primary hypoalphalipoproteinemia remain controversial and should be supervised by a healthcare provider.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypoalphalipoproteinemia Primary 1 C5231558?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Circulation. 2019.
Tall AR, Rader DJ. Trials and Tribulations of CETP Inhibitors. Circ Res. 2018.
Nagai Y, Hattori H, Kurosawa H, et al. Efficacy and Safety of Volanesorsen in Patients with Hypertriglyceridemia and Hypoalphalipoproteinemia: A Phase 2 Study. J Clin Lipidol. 2022.
He Y, Zhang Y, Li W, Wang Q. HDL Function and Cardiovascular Outcomes in Patients with Low HDL Cholesterol: A Systematic Review and Meta-Analysis. Eur Heart J. 2021.
Medication Comparisons
Compare medications used to treat Hypoalphalipoproteinemia Primary 1 C5231558. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy