Hypogonadotropic Hypogonadism 3 Without Anosmia C4017072
A hormone deficiency affecting sexual development and reproduction. Caused by genetic factors, it does not involve loss of smell. Hormone replacement therapy is the main treatment.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Decreased libido
(reproductive)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Fatigue
(endocrine)Amenorrhea
(reproductive)Sparse body hair
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Gonadotropin Replacement Therapy
Physiologic replacement of luteinizing hormone and follicle-stimulating hormone to stimulate endogenous sex hormone production and support normal puberty progression or restoration of reproductive function.
Pulsatile GnRH Administration
For patients without pituitary pathology, pulsatile gonadotropin-releasing hormone delivered via infusion pump can stimulate physiologic gonadotropin secretion and restore hormonal function.
Additional treatment options
Hormonal and Metabolic Monitoring
Regular assessment of sex hormone levels, bone density, metabolic markers, and pubertal development to optimize replacement regimens and detect complications early in hypogonadotropic hypogonadism management.
monitoringPsychological Support Services
Counseling and psychological support addressing body image concerns, fertility anxiety, and social adjustment issues common in patients with delayed puberty or hypogonadism-related conditions.
psychologicalFertility Preservation Procedures
Sperm cryopreservation or other fertility preservation options discussed with post-pubertal patients before initiating treatment, given the potential impact on future reproductive options.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypogonadotropic Hypogonadism 3 Without Anosmia C4017072?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Boehm U, Bouloux PM, Dattani MT, et al. Expert consensus on the diagnosis and treatment of congenital hypogonadotropic hypogonadism. Endocr Rev. 2021.
Maione L, Young J. Genetics of hypogonadotropic hypogonadism: what has been learned from clinical studies? Curr Opin Endocrinol Diabetes Obes. 2022.
Pitteloud N, Quinton R, Pearce S, et al. Efficacy and safety of pulsatile GnRH therapy in normosmic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2020.
Silva JP, von Stulpnagel C, Dattani MT. Genetic spectrum and phenotype analysis of FGFR1-related hypogonadotropic hypogonadism: a systematic review. Eur J Endocrinol. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy