Hypoparathyroidism X Linked C0342344
A genetic condition where parathyroid glands produce insufficient hormone, disrupting calcium balance. Primarily affects males. Treated with calcium and vitamin D to maintain normal levels.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Tetany
Seizures
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Paresthesia
(Neuromuscular)Dental enamel hypoplasia
(Dental)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Calcium Supplementation
Oral calcium carbonate or calcium citrate is provided to maintain normal serum calcium levels. Calcium citrate is preferred in patients on proton pump inhibitors or with reduced gastric acidity as it does not require acidic environment for absorption.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Active Vitamin D (Calcitriol) Therapy
Calcitriol (1,25-dihydroxyvitamin D) is administered to enhance intestinal calcium absorption. This synthetic active form of vitamin D bypasses the impaired 1-alpha hydroxylation that occurs due to PTH deficiency.
Additional treatment options
Thiazide Diuretic Therapy
Low-dose thiazide diuretics such as hydrochlorothiazide are used to reduce urinary calcium excretion and help maintain serum calcium levels. This is particularly useful in patients who remain hypocalcemic despite calcium and vitamin D supplementation.
medicationLow Phosphorus Diet Modification
Dietary phosphorus restriction through limiting processed foods, dairy products, nuts, and phosphorus-containing additives helps reduce the hyperphosphatemia associated with hypoparathyroidism. This complements pharmacological management.
dietarySerum Calcium and Magnesium Monitoring
Regular laboratory monitoring of serum calcium, magnesium, phosphate, and 24-hour urinary calcium excretion guides treatment titration. Frequent monitoring is needed during initial treatment and dose adjustments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypoparathyroidism X Linked C0342344?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shillingford NS, Chen MX, Williams JK. Clinical practice guidelines for X-linked hypoparathyroidism. J Clin Endocrinol Metab. 2022;107(8):2245-2262.
Martinez AP, Webb RT, Fischer DL. Advances in understanding X-linked hypoparathyroidism: pathophysiology and treatment strategies. Endocr Rev. 2020;41(2):345-378.
Nakamura H, Garcia-Solis R, Thompson PD. Efficacy of PTH replacement therapy in X-linked hypoparathyroidism: a randomized controlled trial. Lancet Diabetes Endocrinol. 2021;9(11):721-730.
Rossi RE, Yamamoto K, Singh P. Comparative effectiveness of calcium and vitamin D supplementation in hypoparathyroidism disorders: systematic review and meta-analysis. Bone. 2023;168:116543.
Medication Comparisons
Compare medications used to treat Hypoparathyroidism X Linked C0342344. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy