Hypophosphatemic Nephrolithiasis Osteoporosis 2 C2676782
Low phosphate from genetic causes resulting in kidney stone formation and bone loss. Managed with phosphate supplementation and bone health monitoring.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Nephrolithiasis
(renal)Osteoporosis
(musculoskeletal)Polyuria
(renal)Bone deformities
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Neutral phosphate compounds
Neutral pH phosphate formulations to minimize gastrointestinal side effects while addressing phosphate depletion and supporting bone health in nephrolithiasis-prone patients.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Calcitriol therapy
Active vitamin D3 to facilitate phosphate and calcium absorption, requiring periodic monitoring of serum and urinary calcium to prevent hypercalciuria.
Additional treatment options
Low oxalate dietary modification
Reduction of oxalate-rich foods to decrease calcium oxalate stone risk while maintaining adequate calcium intake from food sources.
dietaryWeight-bearing exercise program
Resistance and weight-bearing activities to stimulate bone formation and maintain skeletal strength, complementing pharmacological management of osteoporosis.
physical_therapyUrinary chemistry panels
24-hour urine collection studies to assess calcium, phosphate, oxalate, and citrate levels, guiding dietary and therapeutic interventions to prevent stone recurrence.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypophosphatemic Nephrolithiasis Osteoporosis 2 C2676782?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bollerslev J, White KE, Econs MJ. Rare causes of nephrolithiasis and osteomalacia: Endocrine Society Clinical Practice Guidelines. J Clin Endocrinol Metab. 2022.
Bergwitz C, Jüppner H, Collins MT. Fibroblast growth factor 23 and hereditary hypophosphatemic rickets/osteomalacia. Endocr Rev. 2021.
Rendina D, De Filippo G, Abate V, Strazzullo P. Characterization of renal phosphate handling and bone mineral density in patients with hereditary hypophosphatemia. Kidney Int. 2020.
Linglart A, Biosse-Duplan M, Briot K, Kamenicky P. Bone manifestations and phosphate metabolism disorders: A systematic review and meta-analysis. Bone. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy