Hypospadias 4 X Linked C3275458
A congenital condition in males with abnormal urethral opening placement. This X-linked form is repaired through surgery with good outcomes.
Key facts at a glance
- ICD-10
- N39.0
- ICD-11
- GA00.0
- Body system
- genitourinary
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abnormal urinary stream
(genitourinary)Generalized symptoms
(genitourinary)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Penile curvature (chordee)
(genitourinary)Foreskin abnormality (hooded foreskin)
(genitourinary)Urinary spraying
(genitourinary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Mathieu Flip-Flap Repair
Parameatal-based flap technique for distal hypospadias repair. The flap is elevated and rotated to create a neomeatus at the tip. Appropriate for select distal lesions with good plate quality.
Onlay Island Flap Urethroplasty
Augmentation urethroplasty using preputial or buccal mucosa graft. The flap is sutured to the urethral plate to widen the urethra without tubularizing the plate itself.
Additional treatment options
Topical Hormone Therapy
Pre-operative application of testosterone cream or dihydrotestosterone to the penis may improve tissue quality and penile size in selected cases, potentially improving surgical outcomes.
medicationLong-term Functional Surveillance
Ongoing assessment of urinary function, cosmesis satisfaction, and sexual function into adulthood. Registry-style follow-up helps identify any late complications or need for revision.
monitoringWound Care Management
Education on post-operative wound care including dressing changes, bath restrictions, and signs of infection or dehiscence. Proper care reduces complication rates and improves outcomes.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypospadias 4 X Linked C3275458?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
European Association of Urology. EAU Guidelines on Genitourinary Malformations: X-linked Hypospadias Management. Eur Urol. 2023.
Baskin LS, Colen TI, Yang SS, et al. Genetic Basis of Hypospadias: Focus on X-linked Forms. J Pediatr Urol. 2021.
Nordenskjöld A, Wilson M, García Fernández A, et al. Surgical Outcomes and Genetic Predictors in X-linked Hypospadias: A Prospective Cohort Study. Urology. 2022.
Mureau MA, van der Steeg A, Roeleveld N. Molecular Mechanisms in Familial Hypospadias: Systematic Review and Meta-analysis. Sex Med Rev. 2020.
Medication Comparisons
Compare medications used to treat Hypospadias 4 X Linked C3275458. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy