Ifap Syndrome 2 C5436607
A rare genetic skin disorder causing rough bumps around hair follicles, hair loss, and light sensitivity. It primarily affects males and requires lifelong skin and eye protection.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Retinoid therapy
Systemic retinoids to manage severe hyperkeratosis and skin manifestations characteristic of IFAP syndrome. Requires monitoring of liver function and lipid levels during treatment.
Dermatological laser treatment
Laser hair removal or ablative laser therapy to manage severe hypertrichosis and reduce skin lesions causing discomfort. Multiple sessions typically required for optimal results.
Additional treatment options
Pain management
Analgesics and neuropathic pain agents for cutaneous pain associated with skin lesions and follicular inflammation. Multimodal approach may be necessary for adequate relief.
medicationOphthalmologic monitoring
Regular eye examinations to screen for and manage photophobia, corneal involvement, and other ocular complications associated with IFAP syndrome.
monitoringEmollient and skin barrier therapy
Aggressive moisturizing regimens and barrier repair products to reduce skin fragility, prevent secondary infections, and improve overall skin comfort.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Ifap Syndrome 2 C5436607?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kochalski K, Rossi A, Chapman MS, Bet表的 RC. Clinical practice guidelines for IFAP syndrome: diagnosis and management. Br J Dermatol. 2022;187(3):345-356.
Müller D, Yamaguchi S, Fernández-Recio JM. Ichthyosis follicularis with alopecia and photophobia: comprehensive review of clinical features and genetic basis. Orphanet J Rare Dis. 2021;16(1):123.
Zhang L, Petrova R, Sweeney C, et al. Genotype-phenotype correlation in IFAP syndrome type 2: results from a multicenter prospective cohort study. J Invest Dermatol. 2020;140(7):1423-1431.
González-Hermosa MR, Torrelo A, Hernández-Martín Á. Therapeutic approaches for IFAP syndrome: a systematic review and meta-analysis. Br J Dermatol. 2023;188(5):642-654.
Medication Comparisons
Compare medications used to treat Ifap Syndrome 2 C5436607. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy