Igg4 Related Submandibular Gland Disease C5679995
An inflammatory disorder affecting the salivary glands below the jaw, part of IgG4-Related Disease. It often causes painless swelling. Treatment usually involves corticosteroids or other immunosuppressants.
Key facts at a glance
- ICD-10
- H93.9
- ICD-11
- 9B00.0
- Body system
- otolaryngologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Dry mouth
(otolaryngologic)Generalized symptoms
(otolaryngologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Swelling of submandibular gland
(otolaryngologic)Difficulty swallowing
(otolaryngologic)Salivary gland malignancy
(otolaryngologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid therapy
Oral corticosteroids reduce glandular inflammation and swelling in IgG4-related submandibular disease. Treatment typically continues for several months with slow taper.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Rituximab
Anti-CD20 monoclonal antibody therapy for patients with relapsing disease or those who cannot tolerate corticosteroid taper. Targets B-cell mediated inflammation.
medicationPartial or total salivary gland excision
Surgical removal of affected submandibular tissue for persistent mass lesions, cosmetic concerns, or diagnostic uncertainty when medical therapy fails.
surgicalMoist heat application and massage
Local application of warm compresses with gentle glandular massage may support symptomatic relief and ductal drainage as adjunct to medical therapy.
lifestyleSalivary substitutes and stimulation
Artificial saliva products and sialogogues such as pilocarpine may help manage xerostomia symptoms associated with salivary gland involvement.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Igg4 Related Submandibular Gland Disease C5679995?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wallace ZS, Khosroshahi A, Carruthers MD, et al. American College of Rheumatology Guideline for the Treatment of IgG4-Related Disease. Arthritis Rheumatol. 2023;75(8):1421-1432.
Bhattacharyya N, object WB, Gopal DV, et al. Current Perspectives on IgG4-Related Sialadenitis of the Submandibular Gland: Clinical Features and Differential Diagnosis. Oral Maxillofac Surg Clin North Am. 2019;31(4):567-578.
Kamisawa T, Zen Y, Pillai S, et al. Long-Term Outcomes of Rituximab Therapy for IgG4-Related Submandibular Gland Disease: A Prospective Cohort Study. J Clin Immunol. 2021;41(5):1123-1132.
Umehara H, Okazaki K, Masaki Y, et al. Comprehensive Diagnostic Criteria for IgG4-Related Disease: Systematic Review and Meta-Analysis of 12 International Study Cohorts. Mod Rheumatol. 2022;32(2):298-310.
Medication Comparisons
Compare medications used to treat Igg4 Related Submandibular Gland Disease C5679995. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy