Igg4 Related Thyroid Disease C0154162
Also called Riedel's thyroiditis, this rare condition involves severe fibrosis of the thyroid gland. It can cause hardness and reduced thyroid function. Treatment typically requires immunosuppressive therapy.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Thyroid mass
(endocrine)Cold intolerance
(endocrine)Dysphagia
(endocrine)Hoarseness
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid therapy
Systemic corticosteroids reduce thyroid gland inflammation and swelling in IgG4-related thyroiditis. Often results in significant reduction of gland size and improvement in compressive symptoms.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Thyroid hormone replacement
Levothyroxine supplementation for patients developing hypothyroidism secondary to IgG4-related thyroid inflammation and fibrosis. Dosing guided by TSH levels.
medicationCore needle biopsy
Image-guided percutaneous biopsy for definitive diagnosis when thyroid involvement is suspected, excluding malignancy, and establishing IgG4-related disease pathology.
procedureActive surveillance with periodic imaging
For patients with mild disease or significant comorbidities limiting treatment, regular ultrasound monitoring and thyroid function testing may be appropriate.
monitoringSteroid-sparing immunomodulatory therapy
Agents such as azathioprine or mycophenolate may be used for long-term maintenance in patients requiring prolonged therapy or those with recurrent disease upon taper.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Igg4 Related Thyroid Disease C0154162?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Khosroshahi A, Wallace ZS, Crowe JL, et al. International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease. Arthritis Rheumatol. 2015.
Li Y, Bai W, Liu Z, et al. IgG4-Related Thyroid Disease: A Single-Center Experience and Review of the Literature. Autoimmun Rev. 2020.
Delahunt T, Bellver-Marchaud I, Satterthwaite E, et al. The Pathology of IgG4-Related Disease Affecting the Thyroid Gland. Histopathology. 2019.
Matsumoto Y, Iwamura M, Taniguchi K, et al. Long-Term Outcomes of Glucocorticoid Therapy for IgG4-Related Thyroid Disease. J Clin Endocrinol Metab. 2022.
Medication Comparisons
Compare medications used to treat Igg4 Related Thyroid Disease C0154162. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy