Immunodeficiency 15a C4748694
A rare genetic immunodeficiency where the immune system doesn't work properly, causing frequent severe infections. Usually appears in childhood. Treatment includes infection prevention, immune support, and careful monitoring.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent infections
(immunologic)B cell deficiency
(immunologic)Autoimmune manifestations
(immunologic)Enteropathy
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Regular IVIG or SCIG infusions providing exogenous antibodies to compensate for impaired humoral immunity. Dosing individualized based on weight, trough levels, and infection burden.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Targeted Antimicrobial Prophylaxis
Customized prophylactic regimen based on specific infection history and sensitivities. May include antibiotics, antifungals, and antivirals depending on documented vulnerabilities.
Additional treatment options
Environmental Control Measures
Systematic reduction of infection sources through HEPA filtration, water safety measures, pet exposure management, and construction zone avoidance. Includes travel precautions for endemic areas.
lifestyleGut Microbiome and Nutritional Optimization
Probiotic supplementation, prebiotic fiber intake, and avoidance of potentially contaminated foods to maintain gut barrier integrity and support mucosal immunity.
dietaryInfection Calendar and Biomarker Tracking
Detailed tracking of all infections, fever episodes, and inflammatory markers to identify patterns and guide prophylaxis adjustments. Includes periodic chest imaging for early lung changes.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency 15a C4748694?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy