Immunodeficiency 66 C5394265
A rare primary immunodeficiency caused by genetic mutations that compromises the body's ability to fight infections.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe disseminated BCG infection after vaccination
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent mycobacterial infections
(pulmonary)Autoimmune arthritis
(musculoskeletal)Granuloma formation
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Intravenous or subcutaneous immunoglobulin replacement provides passive immunity to compensate for antibody deficiency. Regular infusions help prevent recurrent infections and improve quality of life.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Antibiotic Prophylaxis
Continuous low-dose antibiotics reduce the frequency of bacterial infections in immunodeficient patients. Selection depends on common pathogens and local resistance patterns.
Additional treatment options
Regular Immunological Monitoring
Scheduled laboratory assessments track immunoglobulin levels, infection frequency, and organ function to guide treatment adjustments and prevent complications.
monitoringInfection Prevention Measures
Strict hand hygiene, respiratory precautions, and avoidance of crowds minimize exposure to infectious agents. Patient education on recognizing early infection signs is essential.
lifestyleNutritional Support
High-protein diet with adequate micronutrients supports immune function and recovery from infections. Supplementation may be needed for specific deficiencies.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency 66 C5394265?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy