Immunodeficiency 73b With Defective Neutrophil Chemotaxis And Lymphopenia C5436549
A rare immunodeficiency affecting neutrophil movement and lymphocyte levels, impairing the body's defense against infections.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Deep tissue abscesses
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent bacterial infections
(immunologic)Lymphadenopathy
(immunologic)Persistent neutropenia
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Regular immunoglobulin infusions providing broad-spectrum antibody coverage to compensate for both the hypogammaglobulinemia and lymphopenia. This serves as cornerstone therapy for infection prevention in this neutrophil chemotaxis defect.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic Antibiotics
Bacterial infection prophylaxis targeting common pathogens associated with neutrophil dysfunction and impaired chemotaxis. Continuous or cyclic regimens based on infection history and severity.
Additional treatment options
Granulocyte Colony-Stimulating Factor
G-CSF therapy to potentially enhance neutrophil production and function, addressing the chemotaxis defect directly. Treatment response varies and requires careful monitoring.
medicationNutritional Optimization
High-protein, nutrient-dense dietary plan supporting immune function and compensating for increased metabolic demands from recurrent infections. Emphasis on micronutrients critical for immune cell function.
dietaryPhysical Conditioning Program
Supervised exercise program maintaining muscle strength and functional capacity, which can support immune function and overall wellbeing. Particularly important for maintaining pulmonary hygiene.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency 73b With Defective Neutrophil Chemotaxis And Lymphopenia C5436549?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy