Immunodeficiency 73c With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia C5436550
A rare genetic immunodeficiency affecting white blood cells and antibody production, leading to recurrent infections. Treatment includes immunoglobulin therapy and infection prevention measures.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent sinopulmonary infections
(immunologic)Hypogammaglobulinemia
(immunologic)Chronic sinusitis
(immunologic)Fever of unknown origin
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
High-Dose Immunoglobulin Therapy
Aggressive immunoglobulin replacement at higher doses to address both the defective chemotaxis and hypogammaglobulinemia comprehensively. Dosing optimized based on trough levels and infection frequency.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Antifungal and Antibacterial Prophylaxis
Combined antimicrobial prophylaxis addressing the increased susceptibility to both bacterial and fungal infections resulting from neutrophil dysfunction. Regimen tailored to individual exposure risks.
Additional treatment options
Immunonutrition Support
Targeted nutritional supplementation including zinc, selenium, vitamin D, and omega-3 fatty acids to support neutrophil function and modulate inflammation. Dietary counseling for immune-supportive food choices.
dietaryFrequent Infection and Immune Surveillance
Close monitoring for early signs of infection given the particularly high risk from combined chemotaxis defect and antibody deficiency. Regular assessment of neutrophil function and immunoglobulin levels.
monitoringStress Reduction and Mind-Body Practices
Complementary approaches including meditation, yoga, and stress management to support overall immune regulation and reduce inflammation. May help decrease autoinflammatory disease activity.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency 73c With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia C5436550?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy