Immunodeficiency Common Variable 3 C3150738
An immunodeficiency affecting the body's ability to fight infections with antibodies. It varies in severity and often requires lifelong management with immunoglobulin therapy.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent otitis media
(immunologic)Persistent fatigue
(immunologic)Autoimmune neutropenia
(immunologic)Disseminated herpes zoster infection
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Intravenous or subcutaneous immunoglobulin replacement addresses the underlying antibody deficiency. Regular infusions restore IgG levels and provide protection against bacterial infections.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Antibiotic Prophylaxis
Prophylactic antibiotics help prevent recurrent respiratory and sinus infections. Treatment typically involves daily or intermittent antibiotic courses based on infection frequency.
Additional treatment options
Regular Immunologic Monitoring
Scheduled laboratory monitoring of immunoglobulin levels and immune cell populations helps assess disease progression and treatment efficacy. Regular IgG trough levels guide dosing adjustments.
monitoringInfection Prevention Practices
Implementing rigorous hand hygiene, avoiding crowds during peak respiratory seasons, and maintaining up-to-date vaccinations with non-live vaccines reduces infection risk significantly.
lifestyleNutritional Support
Balanced nutrition with adequate protein and micronutrients supports overall immune function. Vitamin D and zinc supplementation may benefit patients with recurrent infections.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency Common Variable 3 C3150738?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Immunodeficiency Common Variable 3 C3150738. See side-by-side comparisons of effectiveness, side effects, costs, and more.
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy