Immunodeficiency With Defective T Cell Response To Interleukin 1 C1855735
A rare disorder where immune cells cannot respond properly to interleukin-1, disrupting immune regulation. Can affect both children and adults. Treatment may involve interleukin-1 targeted therapies.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Defective inflammatory response to infection
(immunologic)Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Impaired fever generation
(immunologic)Reduced erythema and swelling at infection sites
(immunologic)Impaired neutrophil chemotaxis
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Regular intravenous or subcutaneous immunoglobulin infusions to compensate for antibody deficiency and support immune function.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Antibiotic Prophylaxis
Long-term prophylactic antibiotics to prevent bacterial infections given the impaired T-cell and antibody response.
Additional treatment options
Immunological Monitoring
Regular monitoring of immunoglobulin levels, T-cell function, and infection markers to guide treatment adjustments.
monitoringInfection Prevention Practices
Implementation of rigorous hand hygiene, food safety measures, and avoidance of exposure to infectious individuals.
lifestyleVitamin D Supplementation
Supplement vitamin D to support immune function and bone health, particularly important given limited sun exposure during illness.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency With Defective T Cell Response To Interleukin 1 C1855735?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy