Immunodeficiency X Linked With Deficiency Of 115 000 Dalton Surface Glycoprotein C1839982
An X-linked disorder affecting immune function due to deficiency of a specific surface protein. Males are primarily affected. Treatment involves immunoglobulin replacement and infection prevention.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe bacterial infections early in life
(immunologic)Absent B cells
(immunologic)Chronic sinusitis
(immunologic)Failure to thrive
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Regular immunoglobulin G replacement therapy essential for managing X-linked immunodeficiency with 115kDa glycoprotein deficiency. This provides passive immunity and significantly reduces infection frequency and severity.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplantation
Curative approach through allogeneic stem cell transplantation, which can reconstitute a functional immune system. This is particularly considered in patients with severe disease or those with family-matched donors.
Additional treatment options
Antiviral Prophylaxis
Prophylactic antivirals such as acyclovir may be used to prevent herpes family virus infections which these patients are particularly susceptible to, especially following transplant or during periods of immunosuppression.
medicationLymphocyte Subset Analysis
Regular monitoring of T-cell, B-cell, and NK cell counts to assess immune reconstitution status, particularly important post-transplant or in patients on immunoglobulin therapy to ensure comprehensive immune coverage.
monitoringInfection Avoidance Protocol
Strict adherence to infection prevention measures including food safety practices, water quality awareness, and avoidance of exposure to known infected individuals. Annual influenza vaccination and pneumococcal vaccination recommended.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency X Linked With Deficiency Of 115 000 Dalton Surface Glycoprotein C1839982?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Immunodeficiency X Linked With Deficiency Of 115 000 Dalton Surface Glycoprotein C1839982. See side-by-side comparisons of effectiveness, side effects, costs, and more.
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy