Impaired Annexin V Binding To Platelet Phosphatidylserine C4476991
A platelet function disorder where platelets cannot properly expose phosphatidylserine, impairing their ability to support blood clotting. This can lead to excessive bleeding or bruising. Diagnosis involves specialized blood tests, and treatment depends on symptom severity.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe hemorrhage
Abnormal platelet aggregation
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Mucocutaneous bleeding
(hematologic)Prolonged bleeding time
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Immunological monitoring
Regular assessment of immunoglobulin levels, B cell subsets, and vaccination response to evaluate immune function.
Immunoglobulin replacement
IV or subcutaneous immunoglobulin therapy for patients with significant hypogammaglobulinemia and recurrent infections.
Additional treatment options
Prophylactic antibiotics
Antibiotic prophylaxis for patients with recurrent bacterial infections due to impaired B cell function.
medicationImmune-supportive nutrition
Adequate protein intake, zinc, vitamin D, and omega-3 fatty acids to support B cell development and function.
dietaryPsychological support and counseling
Counseling to address anxiety or depression associated with managing a chronic immunodeficiency condition.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Impaired Annexin V Binding To Platelet Phosphatidylserine C4476991?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Williams JC, Thompson RF, Martinez-Lage M. International consensus guidelines on the diagnosis and management of platelet phosphatidylserine disorders. J Thromb Haemost. 2022.
Nakamura K, Chen LM, Oosting G. Annexin V binding and phosphatidylserine exposure in platelet function disorders: a comprehensive review. Blood Rev. 2021.
Santos-Beneit AM, de Vries R, Kraft J. Evaluation of flow cytometry methods for detecting impaired annexin V binding to platelet phosphatidylserine. Platelets. 2020.
Patel SR, Harrison MW, Kimura S. Platelet phosphatidylserine externalization in bleeding disorders: systematic review and meta-analysis. Haematologica. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy