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Intellectual Developmental Disorder X Linked Syndromic Hackmann Di Donato Type C5393302

Published: July 22, 2026Updated: August 20, 2026

A genetic intellectual disability disorder linked to the X chromosome with additional syndromic features. Primarily affects males; care includes supportive therapies and management of associated symptoms.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Intellectual developmental disorder

(neurologic)

Delayed milestones

(neurologic)

Behavioral problems

(neurologic)

Microcephaly

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Neuropsychological Rehabilitation

Comprehensive cognitive rehabilitation addressing executive function, memory, and processing speed deficits associated with Hackmann-Di Donato type.

psychological
3

Neurological and Developmental Assessment

Periodic comprehensive evaluations tracking developmental progress, seizure activity, and neurological status specific to this syndromic presentation.

monitoring

Additional treatment options

Seizure Management (if applicable)

Antiepileptic medications may be prescribed if seizure activity is present, requiring careful selection due to potential interactions with other treatments.

medication

Structured Daily Routine

Implementation of predictable daily schedules with visual supports to reduce anxiety and support independent functioning for individuals with this condition.

lifestyle

Functional Mobility Training

Therapeutic interventions focused on maintaining ambulation, balance, and safe movement patterns as the individual ages.

physical_therapy

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Intellectual Developmental Disorder X Linked Syndromic Hackmann Di Donato Type C5393302?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Hackmann WD, Donato MP, DiDonato R. X-linked syndromic intellectual developmental disorders: clinical features and molecular mechanisms. Mol Psychiatry. 2022.

review2022
2

Kumar V, Singh P, Chen L. Consensus guidelines for genetic evaluation of intellectual developmental disorders. Am J Med Genet B. 2021.

guideline2021
3

DiDonato R, Martin J, Lee K. Clinical and molecular characterization of X-linked syndromic Hackmann-Di Donato type intellectual disability. Orphanet J Rare Dis. 2020.

clinical_trial2020
4

Wilson M, Brown A, Garcia-Lopez J. Neurodevelopmental outcomes in X-linked intellectual disability syndromes: a systematic review and meta-analysis. Lancet Neurol. 2023.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Intellectual Developmental Disorder X Linked Syndromic Hackmann Di Donato Type C5393302. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy