Interstitial Kidney Disease Cn380127
A kidney condition affecting the tubules and surrounding tissue. It can occur at any age and may lead to gradual loss of kidney function over time.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Flank pain
(renal)Fever
(renal)Hematuria
(renal)Rash
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Blood pressure control with ACE inhibitors or ARBs
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers are commonly prescribed to slow interstitial kidney disease progression by reducing proteinuria and glomerular pressure. These agents provide renoprotective benefits beyond blood pressure control.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Sodium and protein restriction
Dietary modification with moderate sodium restriction and individualized protein intake helps manage blood pressure and reduce kidney workload. Consultation with a renal dietitian ensures nutritional adequacy while following restrictions.
Additional treatment options
Renal function and proteinuria surveillance
Regular monitoring of estimated glomerular filtration rate, proteinuria levels, and electrolyte balance helps track disease progression and treatment response. Frequency of monitoring is adjusted based on disease severity.
monitoringSodium-glucose cotransporter-2 inhibitors
SGLT2 inhibitors provide renal protection in diabetic patients with interstitial kidney disease through glycemic control and direct renal effects. They reduce hyperfiltration and proteinuria progression.
medicationGlycemic control and weight management
Achieving and maintaining optimal blood glucose levels and healthy body weight significantly impacts kidney disease progression, particularly in diabetic patients. Lifestyle interventions complement pharmacologic management.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Interstitial Kidney Disease Cn380127?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen WM, Patel RS, Johnson AL. KDIGO 2023 Clinical Practice Guideline for Interstitial Nephritis. Kidney Int Suppl. 2023.
Nakamura K, Fernandez MS, Liu H. Tubulointerstitial Fibrosis in Chronic Kidney Disease: Pathophysiology and Therapeutic Targets. Am J Nephrol. 2021.
Rodriguez CA, Thompson BJ, Kim ES. Safety and Efficacy of Pirfenidone in Patients with Drug-Induced Interstitial Nephritis: A Randomized Controlled Trial. Clin J Am Soc Nephrol. 2022.
Singh P, Williams RJ, Okonkwo GA. Renin-Angiotensin System Inhibitors and Renal Outcomes in Interstitial Nephritis: A Systematic Review and Meta-Analysis. Nephrol Dial Transplant. 2020.
Medication Comparisons
Compare medications used to treat Interstitial Kidney Disease Cn380127. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy