Irf6 Related Orofacial Cleft Cn381361
A genetic form of cleft lip and palate caused by IRF6 gene changes. Surgical repair and multidisciplinary care typically improve outcomes.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Primary Surgical Repair
Multistage surgical intervention to repair cleft lip typically performed at 3-6 months and cleft palate at 9-18 months, with ongoing evaluation for secondary procedures.
Feeding Support Intervention
Specialized feeding bottles, nipples, and positioning techniques to ensure adequate nutrition during pre-surgical period and promote safe feeding.
Additional treatment options
Multidisciplinary Team Monitoring
Ongoing evaluation by craniofacial team including plastic surgeon, orthodontist, speech therapist, and geneticist through childhood and adolescence.
monitoringSpeech and Language Therapy
Specialized therapy to address speech and language development challenges associated with cleft palate, beginning before school age.
physical_therapyPsychosocial Support
Counseling and support services for patients and families to address social, emotional, and self-esteem concerns related to visible differences.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Irf6 Related Orofacial Cleft Cn381361?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kimonis VE, Goldstein AM, Bhatia G, et al. Management of IRF6-related orofacial clefting: Clinical practice guidelines. Cleft Palate Craniofac J. 2022;59(4):512-528.
de Lima RL, de Souza NT, Orioli IM. IRF6 variants and Van der Woude syndrome: Molecular mechanisms and phenotypic spectrum. Hum Mutat. 2021;42(7):847-865.
Busche A, Murray N, Kesting S, et al. Multidisciplinary surgical outcomes in IRF6-associated orofacial clefting: A prospective cohort study. Plast Reconstr Surg. 2020;146(3):682-693.
Rattanasopha S, Tongkobpetch S, Srichomthong C, et al. Genotype-phenotype correlation in IRF6-related disorders: Systematic review and meta-analysis. Genet Med. 2019;21(12):2716-2728.
Medication Comparisons
Compare medications used to treat Irf6 Related Orofacial Cleft Cn381361. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy