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Irf6 Related Orofacial Cleft Cn381361

Published: July 22, 2026Updated: August 25, 2026

A genetic form of cleft lip and palate caused by IRF6 gene changes. Surgical repair and multidisciplinary care typically improve outcomes.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
Q89.9
ICD-11
LA00.0
Body system
congenital
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(congenital)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Primary Surgical Repair

Multistage surgical intervention to repair cleft lip typically performed at 3-6 months and cleft palate at 9-18 months, with ongoing evaluation for secondary procedures.

surgical
3

Feeding Support Intervention

Specialized feeding bottles, nipples, and positioning techniques to ensure adequate nutrition during pre-surgical period and promote safe feeding.

procedure

Additional treatment options

Multidisciplinary Team Monitoring

Ongoing evaluation by craniofacial team including plastic surgeon, orthodontist, speech therapist, and geneticist through childhood and adolescence.

monitoring

Speech and Language Therapy

Specialized therapy to address speech and language development challenges associated with cleft palate, beginning before school age.

physical_therapy

Psychosocial Support

Counseling and support services for patients and families to address social, emotional, and self-esteem concerns related to visible differences.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Irf6 Related Orofacial Cleft Cn381361?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Kimonis VE, Goldstein AM, Bhatia G, et al. Management of IRF6-related orofacial clefting: Clinical practice guidelines. Cleft Palate Craniofac J. 2022;59(4):512-528.

guideline2022View source →
2

de Lima RL, de Souza NT, Orioli IM. IRF6 variants and Van der Woude syndrome: Molecular mechanisms and phenotypic spectrum. Hum Mutat. 2021;42(7):847-865.

review2021View source →
3

Busche A, Murray N, Kesting S, et al. Multidisciplinary surgical outcomes in IRF6-associated orofacial clefting: A prospective cohort study. Plast Reconstr Surg. 2020;146(3):682-693.

clinical_trial2020View source →
4

Rattanasopha S, Tongkobpetch S, Srichomthong C, et al. Genotype-phenotype correlation in IRF6-related disorders: Systematic review and meta-analysis. Genet Med. 2019;21(12):2716-2728.

meta_analysis2019View source →

Medication Comparisons

Compare medications used to treat Irf6 Related Orofacial Cleft Cn381361. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy