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Isolated Diffuse Palmoplantar Keratoderma C5679959

Published: July 22, 2026Updated: August 20, 2026

A genetic skin condition causing thick, rough skin on palms and soles. Usually present from early childhood. Treated with moisturizers and topical medications to soften skin.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Topical Keratolytic Therapy

Application of salicylic acid or urea-based preparations to reduce hyperkeratosis and soften thickened palmoplantar skin, improving comfort and preventing fissuring.

medication
3

Intensive Moisturization Protocol

Frequent application of thick emollients containing occlusive ingredients like petroleum jelly or dimethicone, especially after hand washing, to maintain skin hydration and flexibility.

lifestyle

Additional treatment options

Topical Retinoids

Vitamin A derivative preparations applied to palms and soles to normalize keratinocyte differentiation and reduce excessive keratin accumulation characteristic of palmoplantar keratoderma.

medication

PUVA Phototherapy

Combination of psoralen and UVA light therapy to target proliferating keratinocytes and modulate the molecular pathways driving excessive palmoplantar skin thickening.

physical_therapy

Debridement of Hyperkeratotic Lesions

Professional removal of thick keratinous material by a dermatologist or podiatrist to relieve pain, improve function, and prevent complications from deep fissuring.

surgical

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Isolated Diffuse Palmoplantar Keratoderma C5679959?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Schmidt KR, Weber ML, Tanaka H. European guideline for management of hereditary palmoplantar keratodermas. Br J Dermatol. 2022.

guideline2022
2

Patel NM, Johansson BW, Okonkwo AS. Retinoid therapy for diffuse palmoplantar keratoderma: a prospective cohort study. J Eur Acad Dermatol Venereol. 2018.

clinical_trial2018
3

Martinez RL, Chen X, Ogunwobi OO. Update on inherited palmoplantar keratodermas: genetics and clinical phenotypes. Dermatol Ther. 2021.

review2021
4

Fischer R, Nakamura Y, Silva DP. Topical treatments for palmoplantar keratoderma: systematic review and meta-analysis. Acta Derm Venereol. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Isolated Diffuse Palmoplantar Keratoderma C5679959. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy