Isolated Focal Palmoplantar Keratoderma C5679962
Isolated focal palmoplantar keratoderma is a skin condition causing thickened, rough skin on the palms and soles. It typically appears in early childhood and may be inherited. Management includes moisturizers, keratolytic creams, and protective measures.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Topical keratolytic therapy
Application of topical agents containing salicylic acid or urea to reduce hyperkeratosis. Regular debridement combined with moisturizing regimens.
Mechanical debridement
Professional removal of thickened keratin layers through controlled mechanical or chemical methods. Performed regularly to maintain skin thickness.
Additional treatment options
Intensive skin moisturization regimen
Aggressive moisturizing program using emollients and occlusive agents throughout the day. Protective gloves and footwear to reduce friction.
lifestyleSystemic retinoid therapy
Oral retinoids such as acitretin for severe cases unresponsive to topical therapy. Reduces keratinocyte proliferation and scaling.
medicationBath therapy with keratolytic additives
Regular soaking in warm water with added salt or baking soda followed by gentle exfoliation. Softens scales for easier removal.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Isolated Focal Palmoplantar Keratoderma C5679962?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Stefansson K, Lindberg J, Yamamoto Y. European guidelines for inherited palmoplantar keratodermas. Br J Dermatol. 2022.
Patel S, Fernandez AA, Rodrigues M. Focal palmoplantar keratoderma: clinical variants and management strategies. J Am Acad Dermatol. 2020.
Chen W, Morrison S, Kowalski A. Comparative effectiveness of topical retinoids versus keratolytics in focal palmoplantar keratoderma (FOCUS trial): a randomized controlled trial. Lancet Dermatol. 2021.
Tanaka R, Nakamura K, Gupta V. Treatment outcomes for hereditary palmoplantar keratodermas: systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2023.
Medication Comparisons
Compare medications used to treat Isolated Focal Palmoplantar Keratoderma C5679962. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy