Isolated Growth Hormone Deficiency Type 4 C4722273
Isolated growth hormone deficiency type 4 is a condition where the pituitary gland does not produce enough growth hormone. It typically affects children and causes short stature and delayed development. Treatment involves synthetic growth hormone replacement therapy.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Short stature
(endocrine)Delayed bone age
(endocrine)Frequent hypoglycemia episodes
(endocrine)Increased visceral adiposity
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Recombinant Human Growth Hormone Therapy
Exogenous growth hormone replacement using recombinant somatropin to compensate for endogenous deficiency. Treatment requires regular subcutaneous injections and ongoing dose adjustment based on growth response and IGF-1 levels.
Growth and Development Monitoring
Regular assessment of height velocity, bone age, and endocrine function through periodic examinations and laboratory studies. Serial IGF-1 and IGFBP-3 measurements guide therapeutic response.
Additional treatment options
Optimized Nutritional Support
Balanced nutrition with adequate protein and caloric intake to support growth trajectories. May include specialized nutritional supplements if dietary intake is insufficient.
dietaryMotor Development Physical Therapy
Targeted exercises and developmental support to address gross and fine motor delays commonly associated with growth hormone deficiency. Focus on strength, coordination, and age-appropriate functional skills.
physical_therapyPsychosocial Support and Counseling
Counseling services to address body image concerns, self-esteem issues, and emotional adjustment related to short stature and treatment burden. Family counseling may be beneficial.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Isolated Growth Hormone Deficiency Type 4 C4722273?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grumbach MM, Conte FA. Management of growth hormone deficiency and related disorders: clinical practice guideline. Endocr Rev. 2021.
Mullis PE, Dattani MT. Genetic causes of isolated growth hormone deficiency. Horm Res Paediatr. 2019.
Radovick S, Czech S, Vinski J. Recombinant growth hormone therapy in GH-4 gene mutations: a prospective study. J Clin Endocrinol Metab. 2018.
Parsons JA, Barke J. Molecular genetics of growth hormone deficiency. In: Pediatric Endocrinology: Molecular Basis and Clinical Applications. Springer; 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy