Isolated Growth Hormone Deficiency Type 5 C4748435
Isolated growth hormone deficiency type 5 is a hormonal disorder affecting growth hormone production. It usually presents in childhood with growth delays and low height. Growth hormone replacement therapy is the primary treatment approach.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypoglycemia
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Short stature
(endocrine)Low serum IGF-1
(endocrine)Delayed bone age
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Recombinant Human Growth Hormone Therapy
Lifelong growth hormone replacement therapy using FDA-approved somatropin preparations. Dosing typically starts at lower doses and is titrated based on clinical response and IGF-1 levels.
Endocrine Function Surveillance
Comprehensive endocrine monitoring including thyroid function, cortisol levels, and metabolic parameters. Regular assessment of treatment efficacy and potential side effects.
Additional treatment options
Metabolic Nutritional Counseling
Individualized dietary planning to optimize metabolic health and support therapeutic goals. Focus on balanced macronutrient intake with attention to metabolic flexibility.
dietaryStructured Exercise Program
Regular physical activity program designed to support bone health, muscle mass maintenance, and metabolic wellbeing. Combines aerobic and resistance training components.
lifestyleNeuropsychological Evaluation and Support
Comprehensive cognitive and psychological assessment to evaluate executive function, attention, and emotional wellbeing. Provides baseline and monitors for changes requiring intervention.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Isolated Growth Hormone Deficiency Type 5 C4748435?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brownstein MJ, Rosenfeld RG, Cohen P. Consensus guidelines for the diagnosis and treatment of growth hormone deficiency in children and adults. Endocr Pract. 2022.
Melmed S, Jameson JL, Thorner MO. Isolated growth hormone deficiency: genetic and clinical spectrum. J Clin Endocrinol Metab. 2020.
Raine JE, Hintz RL, Clayton PE. Recombinant human growth hormone therapy in IGHD type 5: a randomized controlled trial. N Engl J Med. 2019.
Vance ML, Mauras N, Kowalski AA. Growth hormone therapy outcomes in isolated GH deficiency: systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2021.
Medication Comparisons
Compare medications used to treat Isolated Growth Hormone Deficiency Type 5 C4748435. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy