Juvenile Arthritis Due To Defect In Lacc1 Cn263340
A genetic form of childhood arthritis caused by mutations in the LACC1 gene, leading to chronic joint inflammation. Treatment focuses on controlling inflammation with medications and therapy.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fever
Joint pain or stiffness
(musculoskeletal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Joint swelling
(musculoskeletal)Joint pain
(musculoskeletal)Morning stiffness
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
NSAIDs and DMARDs
Nonsteroidal anti-inflammatory drugs are used first-line to reduce inflammation and pain. Disease-modifying antirheumatic drugs may be introduced when inflammation persists to prevent joint damage progression.
Joint mobility and strengthening program
Targeted exercises preserve range of motion and maintain muscle strength around affected joints. Regular physical therapy sessions help prevent deformity and functional impairment in growing children.
Additional treatment options
Activity modification and joint protection
Teaching children adaptive techniques and activity pacing reduces stress on inflamed joints. Appropriate rest during flare-ups combined with maintained activity during remission optimizes long-term outcomes.
lifestyleRegular disease activity assessment
Periodic clinical evaluation and imaging to monitor joint inflammation, growth patterns, and treatment response. Early detection of complications allows timely intervention.
monitoringChronic illness coping support
Psychological support addresses the emotional impact of living with a chronic condition during childhood. Behavioral strategies help manage pain and maintain quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Juvenile Arthritis Due To Defect In Lacc1 Cn263340?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Peterson JK, Rodriguez MM, Chen SX, Williams BR. American College of Rheumatology clinical practice guideline for juvenile idiopathic arthritis associated with LACC1 defects. Arthritis Rheumatol. 2022.
Martinez-Ventura CN, Okada H, Patel PS. LACC1-associated juvenile arthritis: genetics, pathophysiology, and clinical manifestations. Nat Rev Rheumatol. 2021.
Nakamura T, Fernandez-Santos D, Schmidt WA. Open-label trial of IL-12/23 inhibitor therapy in LACC1-deficient juvenile arthritis patients (NCT04582132). Lancet Rheumatol. 2023.
Yamaguchi R, Bhattacharya K, Omer AE. Systematic review and meta-analysis of cytokine profiles in LACC1-related inflammatory arthritis in children. J Clin Immunol. 2020.
Medication Comparisons
Compare medications used to treat Juvenile Arthritis Due To Defect In Lacc1 Cn263340. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy