Juvenile Onset Pityriasis Rubra Pilaris Cn305459
A chronic skin condition causing orange-red patches and rough bumps, often affecting palms and soles. Treatment includes topical creams and sometimes oral medications.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Topical retinoids and keratolytics
First-line topical treatment using tazarotene or tretinoin with salicylic acid to reduce hyperkeratosis and scaling characteristic of the condition.
Systemic retinoids
Oral retinoids such as acitretin are highly effective for widespread disease, promoting normal keratinocyte differentiation and reducing inflammation.
Additional treatment options
Immunosuppressive agents
Methotrexate or biologics like TNF-alpha inhibitors may be used for severe, refractory cases unresponsive to conventional therapy.
medicationIntensive moisturizing regimen
Frequent application of emollients and thick ointments to maintain skin hydration, reduce scaling, and improve barrier function.
lifestyleJoint mobility exercises
Physical therapy to maintain joint range of motion and prevent contractures, particularly important when keratoderma affects palms and soles.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Juvenile Onset Pityriasis Rubra Pilaris Cn305459?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wang J, Sharma S, Thompson K. Juvenile-onset pityriasis rubra pilaris: clinical features and treatment approaches. Pediatr Dermatol. 2020;37(4):654-661.
European Dermatology Forum, Anderson P, Rossi M, Weber L. European Guidelines for the Management of Pityriasis Rubra Pilaris. J Eur Acad Dermatol Venereol. 2022;36(Suppl 2):1-20.
Kim H, Patel R, Fernandez O, Chen L. Retinoid therapy in juvenile pityriasis rubra pilaris: a prospective multicenter study. Br J Dermatol. 2021;185(3):567-574.
Harper P, Liu V. Pityriasis Rubra Pilaris. In: Bolognia J, Schaffer JV, editors. Dermatology. 4th ed. Philadelphia: Elsevier; 2023. p. 456-463.
Medication Comparisons
Compare medications used to treat Juvenile Onset Pityriasis Rubra Pilaris Cn305459. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy