Kaposi Sarcoma C0036220
A cancer caused by a virus that creates abnormal blood vessel growth, forming red or purple patches on skin or mucous membranes. It often affects people with weakened immune systems. Treatment includes chemotherapy, radiation, and antiretroviral therapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Gastrointestinal bleeding
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Violaceous skin nodules or plaques
(integumentary)Mucosal lesions in the oral cavity
(gastrointestinal)Lymphedema of extremities
(lymphatic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antiretroviral Therapy
Combined antiretroviral therapy is the cornerstone of treatment for AIDS-related Kaposi sarcoma, as it suppresses HIV replication and allows immune reconstitution, often leading to KS regression.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Systemic Chemotherapy
Liposomal anthracyclines such as doxorubicin represent first-line chemotherapy for advanced or widespread Kaposi sarcoma, offering superior efficacy with reduced toxicity.
Additional treatment options
Local Radiation Therapy
Localized radiation therapy effectively controls symptomatic or disfiguring lesions, particularly those causing pain, bleeding, or lymphedema in accessible areas.
procedureImmunotherapy with Interferon-alpha
Interferon-alpha provides antiviral and antiproliferative effects and may be used in patients with relatively preserved immune function who cannot tolerate chemotherapy.
medicationIntralesional Therapy
Intralesional injection of chemotherapy agents or interferons directly into accessible lesions provides local control with minimal systemic toxicity.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Kaposi Sarcoma C0036220?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Kaposi Sarcoma C0036220. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy