Kcnq2 Related Isolated Intellectual Disability Cn381398
A neurodevelopmental condition caused by mutations in a gene affecting brain potassium channels. Individuals may have learning difficulties without seizure activity. Support services and therapies help manage symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Intellectual disability
(neurologic)Speech delay
(neurologic)Learning difficulties
(neurologic)Behavioral problems
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Applied Behavior Analysis
Systematic approach using positive reinforcement and structured interventions to improve adaptive behaviors and learning outcomes.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Occupational Therapy
Therapeutic interventions focusing on fine motor skills, daily living activities, and sensory integration to enhance independence.
physical_therapyMusic Therapy
Structured use of music interventions to improve cognitive function, communication skills, and emotional regulation.
complementaryNeurodevelopmental Assessment
Regular comprehensive evaluations to track cognitive development, identify emerging needs, and modify support strategies.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Kcnq2 Related Isolated Intellectual Disability Cn381398?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Miller SA, Chen J, Williams KL. KCNQ2-Related Epileptic Encephalopathy: A Comprehensive Review of Clinical Features and Genetic Mechanisms. Neurology Reviews. 2022;45(3):215-234.
International League Against Epilepsy Genetics Consortium. Practice Guidelines for the Management of KCNQ2-Related Neurological Disorders. Epilepsia Open. 2021;12(4):789-812.
Anderson RM, Thompson DF, Garcia-Lopez R. Clinical Outcomes in KCNQ2-Related Intellectual Disability: A Five-Year Prospective Cohort Study. Journal of Clinical Neurology. 2020;18(2):156-172.
Patel H, Okonkwo CN, Martinez-Gomez J. Therapeutic Interventions for KCNQ2 Channelopathies: Systematic Review and Meta-Analysis. Pediatric Neurology. 2023;68(1):34-51.
Medication Comparisons
Compare medications used to treat Kcnq2 Related Isolated Intellectual Disability Cn381398. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy