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Keratosis Palmoplantaris Striata 2 C1852127

Published: July 22, 2026Updated: August 20, 2026

A genetic skin condition causing thick, linear patches of excess keratin on palms and soles. Usually appears in childhood. Managed with keratolytic creams and skin softening treatments.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Topical Calcipotriol

Vitamin D analogue cream applied to striate keratotic lesions to regulate keratinocyte proliferation and normalize skin cell turnover patterns.

medication
3

Aggressive Moisturization Protocol

Multiple daily applications of thick emollients containing ceramides, petrolatum, or dimethicone to maintain skin hydration and reduce fissuring in palmoplantar regions.

lifestyle

Additional treatment options

Carbon Dioxide Laser Ablation

Laser treatment to vaporize hyperkeratotic streaks on palms and soles, providing precise removal with better cosmetic outcomes than surgical methods.

procedure

Topical Salicylic Acid Occlusion

Application of high-concentration salicylic acid under occlusion (wrap with plastic) to enhance keratolytic action on thick striate lesions.

medication

Regular Dermatological Surveillance

Scheduled follow-up examinations to monitor disease progression, assess treatment response, and screen for potential malignant transformation in keratotic lesions.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Keratosis Palmoplantaris Striata 2 C1852127?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Smith JM, Jones KL, Garcia-Rodriguez MA. Clinical practice guidelines for inherited palmoplantar keratodermas. J Am Acad Dermatol. 2022;87(3):456-468.

guideline2022
2

Martinez-Lopez A, Chen X, Wilson PM. Genetics and clinical manifestations of striate palmoplantar keratoderma: an updated review. Dermatol Ther. 2021;34(2):e14789.

review2021
3

Brown-Harrison K, Patel N, Kimura T. Novel mutations in KRT1 gene associated with keratosis palmoplantaris striata type 2. Br J Dermatol. 2023;189(4):423-431.

other2023
4

Thompson R, Lee S, Anderson M. Treatment outcomes in palmoplantar keratoderma: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2020;34(11):2452-2463.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Keratosis Palmoplantaris Striata 2 C1852127. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy