Kidney Medullary Carcinoma C4049328
An uncommon, aggressive kidney cancer often associated with sickle cell trait. Treatment usually involves surgery and may require additional therapies.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Gross hematuria
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Flank pain
(renal)Palpable abdominal mass
(renal)Unexplained weight loss
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Radical Nephrectomy
Complete surgical removal of the affected kidney along with the adrenal gland and surrounding fatty tissue. This is the primary treatment approach for kidney medullary carcinoma, which is often diagnosed at an advanced stage.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Chemotherapy
Systemic chemotherapy using platinum-based agents, typically in combination with other drugs. Given the aggressive nature of medullary carcinoma and its resistance to standard RCC therapies, chemotherapy is often employed as part of multimodal treatment.
Additional treatment options
Radiation Therapy
External beam radiation therapy may be used for local tumor control or palliation of symptoms in cases with localized recurrence or symptomatic metastatic disease.
procedureImmunotherapy
Immune checkpoint inhibitors may be considered in advanced or metastatic cases where standard chemotherapy has failed. These agents work by enhancing the body's immune response against cancer cells.
medicationPalliative and Supportive Care
Multidisciplinary supportive care focusing on symptom management, pain control, and quality of life improvement. Includes nutritional support, psychological counseling, and management of treatment-related side effects.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Kidney Medullary Carcinoma C4049328?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy