Kidney Osteogenic Sarcoma C1335747
A very rare bone cancer that can occur in the kidney, most often in young people. Treatment typically includes surgery and chemotherapy, requiring specialized care.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Gross hematuria
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Flank pain
(renal)Palpable abdominal mass
(renal)Unexplained weight loss
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Radical Nephrectomy with Adjacent Tissue Resection
Surgical removal of the kidney with wide margins including any involved adjacent structures. Given the rarity and aggressive behavior of renal osteogenic sarcoma, complete surgical excision with clear margins is essential.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Adjuvant Chemotherapy
Systemic chemotherapy following surgery, similar to protocols used for osteosarcoma in other locations. Typically involves multi-agent regimens including doxorubicin, cisplatin, and high-dose methotrexate.
Additional treatment options
Targeted Therapy
Tyrosine kinase inhibitors or other molecularly targeted agents may be considered based on available genetic profiling. These therapies aim to inhibit specific pathways involved in tumor growth.
medicationRadiation Therapy
Adjuvant or definitive radiation therapy may be used when surgical margins are positive or when complete resection is not feasible. Helps reduce local recurrence risk.
procedureSurveillance and Metastatic Monitoring
Regular imaging studies including CT scans and chest X-rays to monitor for metastatic disease, particularly to the lungs which is common with osteogenic sarcomas. Includes routine laboratory assessments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Kidney Osteogenic Sarcoma C1335747?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy