Kidney Pelvis Sarcomatoid Transitional Cell Carcinoma C1335752
A rare, aggressive cancer of the kidney's collecting system with poor prognosis. Treatment typically involves surgery and may include chemotherapy or targeted therapy.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hematuria
Flank pain
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Weight loss
(systemic)Fatigue
(systemic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Radical Nephroureterectomy
Complete surgical removal of the kidney, ureter, and a cuff of bladder tissue. This is the standard surgical approach for upper tract urothelial carcinomas including those with sarcomatoid features, ensuring complete removal of the tumor.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Adjuvant Chemotherapy
Platinum-based chemotherapy following surgery, particularly in cases with high-grade tumors, lymph node involvement, or advanced stage disease. Helps reduce risk of systemic recurrence.
Additional treatment options
Immunotherapy
Immune checkpoint inhibitors have shown activity in advanced urothelial carcinoma and may be used in the adjuvant setting or for metastatic disease following chemotherapy.
medicationLymph Node Dissection
Removal of regional lymph nodes during surgery for staging purposes and potential therapeutic benefit. Extent of dissection depends on tumor location and preoperative imaging findings.
procedureBladder Instillation Therapy
Intravesical chemotherapy or BCG therapy may be considered post-operatively to reduce risk of bladder recurrence, which is elevated in upper tract urothelial carcinoma patients.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Kidney Pelvis Sarcomatoid Transitional Cell Carcinoma C1335752?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy