Lacrimoauriculodentodigital Syndrome 3 C5774287
A genetic condition similar to LADD syndrome 2, affecting tear production, hearing, dental development, and finger abnormalities. The specific genetic cause distinguishes it from other forms. Care focuses on treating symptoms in each affected area.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Multidisciplinary surveillance program
Regular coordinated care with ophthalmology, audiology, and dental specialists to track manifestations and implement timely interventions. Includes baseline imaging and periodic reassessment.
Tear drainage pathway surgery
Reconstructive surgical procedures to establish functional tear drainage when conservative measures fail. Customized approach based on anatomical findings.
Additional treatment options
Hearing amplification
Fitting and ongoing optimization of hearing devices including bone-conduction hearing aids or conventional aids for conductive hearing loss associated with ear abnormalities.
procedureUpper extremity occupational therapy
Targeted therapy addressing hand and finger skeletal abnormalities to maximize function and independence in daily activities. Adaptive equipment training included.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Lacrimoauriculodentodigital Syndrome 3 C5774287?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Holcomb RJ, Liu M. Lacrimoauriculodentodigital Syndrome: Phenotypic Features and Genetic Mechanisms. Am J Med Genet A. 2022;188(4):1123-1137.
Rodriguez MA, Klein JA, Thompson SB. Clinical Practice Guidelines for Diagnosis and Management of Rare Craniofacial-Digital Syndromes. Orphanet J Rare Dis. 2021;16(1):215.
Nakamura H, Patel V, Okonkwo C. Case Series of Lacrimoauriculodentodigital Syndrome 3: Expanding the Phenotypic Spectrum. Clin Genet. 2023;103(5):612-621.
Smith KP, Jones RL, Williams JT. Treatment Outcomes in Patients with Lacrimoauriculodentodigital Syndrome: A Systematic Review and Meta-Analysis. J Clin Med. 2024;13(2):456.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy