Late Infantile Juvenile Krabbe Disease Cn200855
A rare genetic nerve disorder that progressively damages the nervous system. Symptoms may include muscle weakness and vision loss. Treatment involves supportive care.
Key facts at a glance
- ICD-10
- E75.23
- ICD-11
- 5A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Vision loss
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Progressive motor decline
(neurologic)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Hematopoietic Stem Cell Transplantation
Early intervention involving bone marrow or cord blood stem cell infusion to replace dysfunctional cells and slow disease progression by providing functional enzyme production.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Symptomatic and Supportive Pharmacotherapy
Targeted medications to manage seizures, spasticity, pain, and other neurological symptoms including anticonvulsants, muscle relaxants, and agents for neuropathic pain management.
medicationSupportive Physical Rehabilitation
Comprehensive therapy program including range of motion exercises, positioning, and adaptive equipment to maintain function, prevent contractures, and optimize quality of life.
physical_therapyMultisystem Surveillance and Management
Regular monitoring of respiratory function, nutritional status, seizure control, and developmental milestones with proactive intervention for complications such as aspiration or infections.
monitoringFamily Support and Quality of Life Measures
Comprehensive support including respite care, genetic counseling for family planning, financial navigation, and palliative care integration to support the entire family unit.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Late Infantile Juvenile Krabbe Disease Cn200855?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Late Infantile Juvenile Krabbe Disease Cn200855. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy