Li Fraumeni Syndrome 1 C1835398
A hereditary cancer syndrome caused by mutations in the TP53 gene. It significantly increases the risk of multiple cancer types at young ages. Lifelong cancer screening and surveillance are essential for affected individuals and families.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Unexplained weight loss
Persistent fatigue
Early-onset palpable mass
Neurological deficit
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive cancer screening program
Annual whole-body MRI combined with organ-specific screenings for breast, colon, brain, and other high-risk cancers. Early detection significantly improves outcomes in this high-risk population.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic mastectomy
Risk-reducing bilateral mastectomy for carriers with elevated breast cancer risk. Significantly reduces breast cancer incidence in high-risk individuals after thorough genetic counseling.
Additional treatment options
Genetic counseling and psychological support
Pre-test and post-test genetic counseling for patients and family members, combined with ongoing psychological support to address cancer anxiety and family planning concerns.
psychologicalCarcinogen avoidance
Lifestyle modifications including smoking cessation, limiting alcohol, avoiding ionizing radiation when possible, and maintaining healthy weight to reduce modifiable cancer risks.
lifestyleCancer-prevention nutrition
Diet rich in fruits, vegetables, and whole grains with limited processed meats. Mediterranean-style dietary patterns may provide additional protective benefits.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Li Fraumeni Syndrome 1 C1835398?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Li Fraumeni Syndrome 1 C1835398. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy