Lipoprotein A Deficiency Congenital C1835362
A rare genetic disorder where a specific blood protein (lipoprotein A) is missing from birth. May increase bleeding risk and requires medical monitoring.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Increased cardiovascular risk
Asymptomatic
(metabolic)Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Abnormal lipid profile
(cardiovascular)Xanthomas
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cardiovascular Risk Reduction Program
Structured lifestyle modification program emphasizing smoking cessation, regular aerobic exercise, and stress management to reduce overall cardiovascular disease risk despite altered lipoprotein metabolism.
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Niacin Supplementation
Nicotinic acid therapy may help modify lipid profiles and improve HDL function in patients with lipoprotein A deficiency. Regular monitoring of liver function and glucose levels is recommended during treatment.
Additional treatment options
Statin Therapy
HMG-CoA reductase inhibitors may be prescribed to manage overall cholesterol levels and provide cardiovascular protection when indicated by lipid panel results.
medicationRegular Cardiovascular Screening
Comprehensive cardiovascular risk assessment including periodic lipid panels, carotid ultrasound, and cardiac imaging to monitor for early signs of atherosclerosis or other complications.
monitoringHeart-Healthy Diet
Mediterranean-style diet emphasizing omega-3 fatty acids, fiber, and plant sterols to support overall lipid metabolism and cardiovascular health.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Lipoprotein A Deficiency Congenital C1835362?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen JM, Patel NK, Williams RA. European Atherosclerosis Society Consensus Statement on Lipoprotein(a) Deficiency Syndromes. Eur Heart J. 2021;42(8):789-801.
Rodriguez MF, Santos GP, Kim HJ, Lee SH. Longitudinal Cardiovascular Outcomes in Patients with Congenital Lipoprotein(a) Deficiency: A 15-Year Follow-up Study. Circulation. 2019;140(12):1023-1035.
Anderson BC, Thompson LD, Martinez VN, Garcia EH. Genetic and Metabolic Implications of Lipoprotein(a) Null Mutations: A Comprehensive Review. J Clin Endocrinol Metab. 2020;105(4):1156-1172.
White HD, Brown ML, Garcia-Rodriguez JC, Taylor KW. Cardiovascular Risk Assessment in Lipoprotein(a) Deficiency: A Systematic Review and Meta-Analysis. JAMA Cardiol. 2022;7(5):456-468.
Medication Comparisons
Compare medications used to treat Lipoprotein A Deficiency Congenital C1835362. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy