Lissencephaly Due To Tuba1a Mutation C4305153
A brain malformation caused by mutations in the TUBA1A gene affecting brain development. It leads to severe developmental delays and neurological problems. Treatment focuses on supportive care and managing symptoms.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Epilepsy
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe developmental delay
(neurologic)Hypotonia
(neurologic)Feeding difficulties
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antiepileptic medication management
Comprehensive seizure management using antiepileptic drugs tailored to the patient's specific seizure manifestations. Drug levels and side effects should be monitored regularly.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Early intensive physical rehabilitation
Early intervention program focusing on motor development, muscle tone management, and functional mobility. Includes positioning techniques and therapeutic exercises.
Additional treatment options
Neurodevelopmental surveillance
Ongoing assessment of cognitive development, motor milestones, and neurological status through regular developmental pediatrics and neurology visits.
monitoringFamily-centered psychological support
Counseling and support services for families affected by TUBA1A-related lissencephaly. Includes coping strategies, genetic counseling, and connection to support networks.
psychologicalAdjunctive therapeutic approaches
Complementary therapies such as music therapy, hydrotherapy, or sensory integration therapy may provide additional benefits for development and quality of life.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Lissencephaly Due To Tuba1a Mutation C4305153?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy