Lissencephaly With Cerebellar Hypoplasia Type A C5191423
A severe brain disorder combining lissencephaly with underdevelopment of the cerebellum. It affects children and causes profound developmental impairment and movement difficulties. Care involves supportive therapies and multidisciplinary management.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Cerebellar ataxia
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Developmental delay
(neurologic)Microcephaly
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cerebellar-focused rehabilitation program
Specialized physical therapy addressing cerebellar dysfunction including ataxia, balance problems, and coordination deficits common with cerebellar hypoplasia type A.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Movement disorder and tone management
Pharmacological management of associated movement disorders, increased muscle tone, and spasticity that frequently accompany cerebellar hypoplasia in lissencephaly.
Additional treatment options
Neurodevelopmental and cerebellar function monitoring
Regular assessment of cerebellar signs including ataxia progression, coordination, and balance. Imaging may be repeated to assess structural changes.
monitoringFeeding and swallowing rehabilitation
Specialized assessment and management of feeding difficulties and dysphagia associated with cerebellar involvement, potentially including modified food textures and feeding strategies.
dietaryCognitive and behavioral support services
Neuropsychological evaluation and support services addressing cognitive challenges, behavioral issues, and educational needs associated with lissencephaly with cerebellar hypoplasia.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Lissencephaly With Cerebellar Hypoplasia Type A C5191423?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy