Lissencephaly With Cerebellar Hypoplasia Type F C4274989
A genetic form of lissencephaly with additional cerebellar hypoplasia. It results in severe developmental and motor problems. Treatment involves multidisciplinary supportive care approaches.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spasticity
(neurologic)Failure to thrive
(neurologic)Cortical visual impairment
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Early intervention physical therapy
Intensive physical therapy program focused on motor development, muscle tone management, and functional mobility. Therapists work on positioning, stretching, and developmental milestones.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Anticonvulsant therapy
Seizure management through appropriate anticonvulsant medications selected based on seizure type and patient tolerance. Regular monitoring for efficacy and side effects.
Additional treatment options
Neurodevelopmental surveillance
Regular comprehensive evaluations including neuroimaging, developmental assessments, hearing and vision screenings, and endocrine function tests to detect complications early.
monitoringGastrostomy tube placement
Surgical placement of feeding tube for patients with significant dysphagia or failure to thrive who cannot meet nutritional needs orally. Provides reliable nutrition and medication administration.
surgicalOccupational therapy services
Occupational therapy addressing self-care skills, sensory integration, and upper extremity function. Focuses on maximizing independence in daily activities appropriate to developmental level.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Lissencephaly With Cerebellar Hypoplasia Type F C4274989?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy