Liver Diffuse Large B Cell Lymphoma C2184126
An aggressive cancer of white blood cells that can develop primarily in the liver or spread there. It mainly affects adults and may cause liver enlargement or dysfunction. Treatment typically involves chemotherapy and targeted therapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abdominal pain
Jaundice
Constitutional B symptoms
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hepatomegaly
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
R-CHOP chemotherapy regimen
Standard first-line chemotherapy combining rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone. Targets CD20 on B-cells and rapidly proliferating cancer cells.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Liver biopsy with immunohistochemistry
Image-guided core needle biopsy of hepatic lesion to establish definitive diagnosis, subtype classification, and immunohistochemical markers guiding treatment selection.
Additional treatment options
Response assessment imaging
Serial CT or PET-CT scans at defined intervals to assess treatment response using standardized criteria. Guides continuation, modification, or completion of therapy.
monitoringHepatic resection in select cases
Surgical removal of localized hepatic involvement when disease is confined and patient has adequate hepatic reserve. Combined with systemic therapy for optimal outcomes.
surgicalNutritional support during chemotherapy
Comprehensive nutritional assessment and intervention including appetite stimulants, supplemental nutrition, and electrolyte management to maintain strength during intensive therapy.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Liver Diffuse Large B Cell Lymphoma C2184126?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Liver Diffuse Large B Cell Lymphoma C2184126. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy