Low Blood Neutrophil Counts Anc 1 5 X 109 L And Recurrent Bacterial Infections Usually Beginning Very Early In Childhood Cn186324
Severe congenital neutropenia is a condition where the body lacks enough neutrophils, a type of white blood cell that fights bacterial infections. Individuals with this condition experience recurrent bacterial infections starting in early childhood. Treatment typically involves daily antibiotic prevention and granulocyte colony-stimulating factor to boost neutrophil production.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pneumonia
Recurrent bacterial infections
Skin infections
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Oral ulcers
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Granulocyte colony-stimulating factor (G-CSF)
G-CSF is the primary treatment for severe congenital neutropenia, stimulating neutrophil production in the bone marrow. Regular subcutaneous injections significantly reduce infection incidence.
Antibiotic prophylaxis
Prophylactic antibiotics, particularly trimethoprim-sulfamethoxazole, help prevent bacterial infections during periods of neutropenia. May be used continuously or during high-risk periods.
Additional treatment options
Hematopoietic stem cell transplantation
For patients who develop leukemia, have poor G-CSF response, or have severe disease, stem cell transplant offers potential cure. This is reserved for refractory cases or those with malignant transformation.
surgicalInfection prevention practices
Rigorous hand hygiene, food safety measures, and avoidance of crowded environments reduce exposure to pathogens. Patients and families receive education on early infection recognition.
lifestyleRegular ANC monitoring
Frequent complete blood count monitoring tracks neutrophil trends and guides treatment adjustments. More frequent monitoring during dose changes or illness.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Low Blood Neutrophil Counts Anc 1 5 X 109 L And Recurrent Bacterial Infections Usually Beginning Very Early In Childhood Cn186324?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy