Macroglobulinemia Waldenstrom 1 C1835192
A rare blood cancer where the body makes too much of a certain protein, causing the blood to thicken. It can cause fatigue, bleeding, and nerve problems. Treatment may include chemotherapy and targeted therapies.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hyperviscosity symptoms
Bleeding
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Peripheral neuropathy
(hematologic)Lymphadenopathy
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-CD20 Monoclonal Antibody Therapy
Rituximab-based regimens targeting malignant B-cells to achieve disease control and reduce IgM levels.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Therapeutic Plasma Exchange
Apheresis procedure to rapidly reduce circulating IgM proteins and manage hyperviscosity syndrome symptoms.
Additional treatment options
Proteasome Inhibitor Therapy
Bortezomib-based regimens may be used for refractory disease or in combination strategies.
medicationSerum IgM and Viscosity Surveillance
Regular laboratory monitoring of immunoglobulin levels and clinical assessment for hyperviscosity symptoms.
monitoringHydration and Infection Prevention
Adequate fluid intake and infection precautions given immunocompromised state and treatment effects on immunity.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Macroglobulinemia Waldenstrom 1 C1835192?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Macroglobulinemia Waldenstrom 1 C1835192. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy