Major Depressive Disorder 2 C1837529
This form of depression involves prolonged feelings of sadness and emptiness. Treatment typically includes psychotherapy, antidepressants, or combination therapy along with support.
Key facts at a glance
- ICD-10
- F99
- ICD-11
- 6A00.0
- Body system
- psychiatric
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Suicidal ideation
Mood changes or anxiety
(psychiatric)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Depressed mood
(psychiatric)Hypersomnia
(psychiatric)Weight gain
(psychiatric)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors)
Dual-action antidepressants that increase both serotonin and norepinephrine levels. Particularly useful when fatigue or low energy accompanies depressive symptoms.
Interpersonal Therapy (IPT)
Brief focused psychotherapy addressing interpersonal relationships and social roles that may contribute to depression. Emphasizes improving communication skills and resolving conflicts.
Additional treatment options
Mindfulness-Based Stress Reduction
Structured program combining mindfulness meditation, body awareness, and gentle yoga. Reduces rumination and emotional reactivity while promoting present-moment awareness.
complementarySleep Hygiene Optimization
Behavioral interventions establishing consistent sleep-wake cycles, limiting screen exposure before bed, and creating optimal sleep environment. Addresses circadian rhythm disturbances common in depression.
lifestyleCollaborative Care Monitoring
Regular coordination between primary care and mental health specialists with systematic follow-up protocols. Includes patient tracking, outcome measurement, and care coordination.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Major Depressive Disorder 2 C1837529?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Psychiatric Association. Practice Guideline for the Treatment of Patients with Major Depressive Disorder, Third Edition. Am J Psychiatry. 2021;173(Supplement 1):1-152.
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018;391(10128):1357-1366.
Daly EJ, Trivedi MH, Janik A, Li H, Zhang Y, Li X, et al. Efficacy of Adjunctive Intranasal Esketamine in Treatment-Resistant Depression: A Randomized Clinical Trial. JAMA Psychiatry. 2019;76(9):893-903.
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, et al. Major Depressive Disorder. Nat Rev Dis Primers. 2016;2:16065.
Medication Comparisons
Compare medications used to treat Major Depressive Disorder 2 C1837529. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy