Male Sterility Due To Y Chromosome Deletions C2931163
A genetic cause of male infertility from deletions on the Y chromosome that disrupt sperm production. It affects males seeking to father children naturally.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Male infertility
(reproductive)Decreased libido
(reproductive)Testicular atrophy
(reproductive)Gynecomastia
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Intracytoplasmic sperm injection (ICSI)
This advanced assisted reproductive technology involves injecting a single sperm directly into an egg, often the most effective option for men with Y chromosome microdeletions who produce any sperm.
Fertility counseling and support
Professional psychological support helps patients and couples cope with the emotional challenges of infertility diagnosis and navigate complex reproductive decisions.
Additional treatment options
Testicular sperm extraction (TESE)
Surgical retrieval of sperm directly from testicular tissue may be attempted for men with non-obstructive azoospermia, with retrieved sperm used for ICSI.
procedureHormonal and genetic monitoring
Regular endocrine function tests and genetic counseling help manage associated hormonal imbalances and provide comprehensive information about the condition.
monitoringSperm donation consultation
For couples who cannot achieve pregnancy with patient's own sperm, consultation about donor sperm options provides alternative pathways to parenthood.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Male Sterility Due To Y Chromosome Deletions C2931163?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Chianese C. Genetic basis of male infertility: Y chromosome microdeletions. Hum Reprod Update. 2020.
Jungwirth A, Giwereman A, Götz H, et al. European Association of Urology Guidelines on Male Infertility. Eur Urol. 2022.
Silber SJ, Repping S. Birth of healthy children after intracytoplasmic sperm injection in men with Yq microdeletions. Fertil Steril. 2019.
Zhang F, Lu C, Li Z. Y chromosome microdeletions and male infertility: A systematic review and meta-analysis. Andrology. 2021.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy