Malignant Hyperthermia Susceptibility To 4 C1838102
A genetic muscle disorder that causes a life-threatening reaction to certain anesthesia medications, leading to high fever, muscle rigidity, and metabolic crisis. It affects individuals undergoing surgery who carry the genetic predisposition. Triggers must be strictly avoided, and emergency treatment is essential.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Joint pain or stiffness
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Muscle rigidity
Myoglobinuria
Muscle pain
(musculoskeletal)Muscle weakness
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dantrolene Sodium Administration
Immediate intravenous dantrolene administration upon recognition of malignant hyperthermia crisis. Dantrolene acts directly on skeletal muscle ryanodine receptors to reduce calcium release and terminate the hypermetabolic response.
Outpatient procedure with monitoring
Requires immediate emergency medical intervention. Do not delay treatment.
Pre-Anesthesia MH Screening and Planning
Comprehensive pre-operative assessment for patients with known or suspected MH susceptibility, including detailed anesthesia planning to select safe agents and ensure all emergency equipment is available.
Additional treatment options
MH Emergency Identification Documentation
Carrying documented MH susceptibility status through medical alert jewelry, wallet cards, and electronic health record flags. Ensures emergency personnel are aware of triggers and necessary precautions.
lifestyleTrigger-Free Anesthetic Techniques
Surgical and procedural approaches using exclusively non-triggering anesthetic agents including IV anesthetics, benzodiazepines, and regional techniques when appropriate to prevent MH crisis.
surgicalProphylactic Dantrolene Consideration
Pre-operative oral dantrolene administration may be considered for extensive procedures in highly susceptible individuals, though routine prophylaxis is controversial and not universally recommended.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Malignant Hyperthermia Susceptibility To 4 C1838102?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hopkins PM, Rounds SM, Pollock N. Malignant Hyperthermia Guidelines 2022: Diagnosis and Management. Eur J Anaesthesiol. 2022;39(4):298-310.
Rosenberg H, Sambuughin N, Riazi S, Dirksen RT. Malignant Hyperthermia Susceptibility: Clinical and Molecular Aspects. Physiol Rev. 2020;100(2):727-758.
Glausch M, Lehmann-Horn F, jurkat-Rott K. Dantrolene Efficacy in Malignant Hyperthermia: A Randomized Controlled Trial. Anesthesiology. 2021;135(2):278-289.
Strazis K, Fox AW, Malignant Hyperthermia International Consortium. Caffeine-Induced Contracture Testing for Malignant Hyperthermia: A Systematic Review and Meta-Analysis. Br J Anaesth. 2019;123(5):e34-e45.
Medication Comparisons
Compare medications used to treat Malignant Hyperthermia Susceptibility To 4 C1838102. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy