Malignant Lymphoma Large B Cell Diffuse C0079744
A fast-growing cancer of B cells, a type of white blood cell. Most common in older adults, it can arise in lymph nodes or organs. Treated with chemotherapy and immunotherapy; many patients achieve remission.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Painless lymphadenopathy
(hematologic)Unexplained weight loss
(systemic)Night sweats
(systemic)Abdominal pain
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP immunochemotherapy
Combination chemotherapy using rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone as standard first-line treatment for diffuse large B-cell lymphoma.
Additional treatment options
Polatuzumab vedotin-based regimens
Novel antibody-drug conjugate therapy combined with bendamustine and rituximab for patients with relapsed or refractory disease, offering alternative mechanism of action.
medicationCentral nervous system prophylaxis
Intrathecal chemotherapy or high-dose methotrexate administration to prevent lymphoma spread to the brain and spinal cord in high-risk patients.
procedureAutologous stem cell transplantation
High-dose chemotherapy followed by rescue with patient's own stem cells for eligible patients with chemotherapy-sensitive relapsed disease.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Malignant Lymphoma Large B Cell Diffuse C0079744?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy