Maturity Onset Diabetes Of The Young Type 2 C0342277
A mild, stable form of diabetes caused by mutations in the GCK gene that results in slightly elevated blood sugar from birth. Often requires no treatment and has a good long-term outlook with minimal complications.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Polyuria
(endocrine)Polydipsia
(endocrine)Weight loss
(endocrine)Blurred vision
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Sulfonylurea agents
Insulin secretagogues that close ATP-sensitive potassium channels in beta cells, stimulating insulin release. Particularly effective for HNF1A-MODY (MODY 2 equivalent in some classification systems).
Low glycemic index diet
Dietary approach emphasizing foods that cause slower rises in blood glucose. Includes whole grains, legumes, vegetables, and foods with demonstrated lower glycemic impact.
Additional treatment options
Regular diabetes screening
Family members should undergo genetic testing and screening for early detection, as MODY type 2 has high penetrance and often presents in adolescence or early adulthood.
monitoringStructured exercise program
Regular aerobic exercise such as walking, cycling, or swimming combined with resistance training to enhance insulin sensitivity and maintain healthy weight.
physical_therapyPsychological support
Counseling and support services to address the emotional impact of chronic disease management and the genetic nature of MODY affecting multiple family members.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Maturity Onset Diabetes Of The Young Type 2 C0342277?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. Diabetes Care. 2022;45(Suppl 1):S17-S38.
Gardner DS, Tai ES. Genetic Testing for Maturity-Onset Diabetes of the Young. Endocrinol Metab Clin North Am. 2021;50(3):475-490.
Hattersley AT, Greeley SAW, Polak M, et al. ISPAD Clinical Practice Consensus Guidelines 2018: The Diagnosis and Management of Monogenic Diabetes in Children and Adolescents. Pediatr Diabetes. 2018;19(Suppl 27):47-63.
Naylor R, Johnson AK, del Gaudio D. Maturity-Onset Diabetes of the Young Overview. In: Adam MP, Mirzaa GM, Pagon RA, et al., editors. GeneReviews. Seattle: University of Washington; 2022.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy