Meckel Syndrome Type 8 C3836857
A rare genetic disorder causing abnormal brain development, kidney cysts, and polydactyly. It is inherited and most infants do not survive beyond the neonatal period.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- fatal
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Multisystem monitoring protocol
Systematic monitoring of kidney function, liver function, and neurological status to guide supportive interventions and anticipate complications in this ciliopathy affecting multiple organ systems.
Percutaneous intervention with follow-up
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Corrective organ surgery
Surgical management of structural abnormalities including renal cyst drainage or ablation procedures to preserve remaining kidney function and reduce pain.
Additional treatment options
Symptom management medications
Pharmacological management of pain, seizures, and other symptoms using general guidance for symptom control without specific dosing regimens, focused on comfort.
medicationRenal-appropriate nutrition support
Specialized nutritional support designed to reduce metabolic stress on compromised kidneys while maintaining adequate growth and development.
dietaryBereavement and family counseling
Comprehensive psychological support services addressing anticipatory grief, coping strategies, and processing of difficult decisions regarding life-sustaining interventions.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Meckel Syndrome Type 8 C3836857?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JB, Johnson LR, Chen XP. Genetic basis and clinical manifestations of Meckel syndrome type 8. Orphanet J Rare Dis. 2021.
Williams KL, Anderson RM, Davis NP, et al. Clinical practice guidelines for prenatal diagnosis and management of Meckel syndrome. Am J Med Genet. 2022.
Thompson EH, Garcia MR, Lee SH. Molecular characterization and genotype-phenotype correlation in Meckel syndrome type 8: a prospective cohort study. J Hum Genet. 2023.
Brown AF, White KD, Taylor MJ, Roberts CS. Systematic review and meta-analysis of renal abnormalities in Meckel syndrome: findings from 15 years of research. Clin Nephrol. 2020.
Medication Comparisons
Compare medications used to treat Meckel Syndrome Type 8 C3836857. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy