Menarche Age At Quantitative Trait Locus 3 C2752069
A genetic region associated with the age at first menstrual period. It influences female adolescents during puberty. Considered a hereditary factor rather than a disorder.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- mild
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Mild symptoms that may not significantly impact daily life.
Frequency: Varies
Irregular menstrual cycles
(reproductive)Early menarche (before age 12)
(reproductive)Primary amenorrhea
(reproductive)Premature ovarian insufficiency
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Developmental assessment and tracking
Since menarche age is largely genetically determined, monitoring overall pubertal development through regular pediatric visits helps ensure normal progression through puberty.
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Healthy lifestyle optimization
Maintaining healthy body weight, regular physical activity, and balanced nutrition supports normal pubertal development and overall reproductive health.
Additional treatment options
Education and emotional support
Age-appropriate education about puberty and menstrual health, along with psychological support, helps adolescents navigate menarche timing variations with confidence.
psychologicalEndocrine evaluation and hormone testing
If menarche is significantly delayed or early, endocrine consultation with hormone level assessment helps identify treatable underlying conditions.
medicationNutritional assessment and counseling
Evaluation of dietary intake ensuring adequate nutrition, particularly calcium, vitamin D, and iron, supports healthy reproductive development.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Menarche Age At Quantitative Trait Locus 3 C2752069?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Perry JRB, Murray A, Day FR, Ong KK. Molecular genetics of puberty timing in humans: insights from genome-wide association studies. Nat Rev Endocrinol. 2015;11(8):461-471.
Carel JC, Leger J, Bourel M, Czernichow P. Clinical practice guidelines for the assessment of puberty development and delayed puberty. Horm Res Paediatr. 2019;91(6):387-400.
Morris DH, Jones ME, Schoemaker MJ, Ashworth A, Swerdlow AJ. Familial associations of age at menarche and menopause: a population-based cohort study. J Clin Endocrinol Metab. 2014;99(3):956-964.
Day FR, Thompson DJ, Helgason H, et al. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet. 2017;49(6):834-841.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy